Objectives: The effect of bladder cancer histological subtypes other than urothelial cancer (UC) on clinical outcomes remains uncertain. We conducted retrospective study to evaluate the clinical outcomes of radical cystectomy in patients with non-UC of the bladder.

Material and Methods: Ninety patients (82 male, 8 female) with mean age of 59.93 years (range: 37-77) who underwent radical cystectomy with bilateral pelvic lymphadenectmy were included. Non-continent diversions were done for sixty three patients while twenty seven patients had continent diversions. The histologic diagnosis was squamous cell carcinoma(SCC) in 56 (62.2%) patients, adenocarcinoma in 8 (8.9%), undifferentiated carcinoma in 15 (16.7%) and other non-UC subtypes in 11 (11.2%). The stages of the tumor were; pT1 (1.1%), pT2 (40.9%), pT3 (44.3%) and pT4 (13.6%).  Lymph node involvement was present in 39.8% of the patients. The mean follow up  period was 19.67+16.27 months.

Results: The five-year disease specific survival rate was 30.8%. Lymphatic invasion and organ confined disease were found to have statistically significant association with survival rates; p= 0.039 and p= 0.0001 respectively.  Mean disease specific survival time(59.23+10.03 months) of patients with SCC was  higher than other subtypes of non-UC (26.23+5.28 months) ,although it was statistically insignificant(p= 0.15).

Conclusion: Lymphatic invasion and organ confined disease are the main predictors of survival, therefore we believe hat extended lymphadenectomy is of much benefit in such patients. Further prospective randomized trials should be carried out to confirm this claim.

عنوان المؤتمر

20. NATIONAL CONGRESS OF UROLOGY - 20. ULUSAL ÜROLOJİ KONGRESİ

دولة المؤتمر

فلسطين

تاريخ المؤتمر

1 نوفمبر، 2008 - 1 نوفمبر، 2008

راعي المؤتمر

NATIONAL CONGRESS OF UROLOGY