Background: Multiple myeloma (MM) frequently causes renal impairment, and a subset of patients progresses to end-stage renaldisease (ESRD) requiring dialysis. Dialysis dependence has historically been considered a relative contraindication to high-doseconditioning and autologous stem cell transplantation (ASCT). Emerging evidence indicates that ASCT may provide efectivehematologic control and, in selected patients, renal recovery.Methods: We conducted a retrospective case series of fve dialysis-dependent patients with MM who underwent ASCT at An-Najah National University Hospital. Demographic and clinical characteristics, transplant variables, supportive-care measures,infectious and noninfectious complications, hematologic recovery, admission and discharge laboratory values, and short-termoutcomes were extracted from the medical records.Results: The fve patients had a mean age of 56 years and received reduced-dose melphalan (140 mg/m 2), followed by peripheral-blood CD34þ cell infusion. The mean CD34þ collection and infusion doses were 4.3 × 106 /kg and 4.1 × 106 /kg, respectively. Allpatients achieved engraftment; mean neutrophil and platelet engraftment occurred on Days 13.0 and 19.4, respectively. Fourpatients (80%) developed neutropenic fever. Clostridioides difcile and Staphylococcus epidermidis were the most frequentlydocumented pathogens. Two patients developed central line–associated bloodstream infection and septic shock. No 100-day

العنوان

Case Reports in Hematology

الناشر

An-Najah National University

بلد الناشر

فلسطين

Indexing

Scopus

معامل التأثير

0,7

نوع المنشور

إلكتروني فقط

المجلد

1808249

السنة

2026

الصفحات

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