This work focuses on the investigation the utilization of 3D-printed dosage forms patient
tailored enteric capsules designed for the modified release of ketoprofen, serving as a model
drug. The research investigates two distinct scenarios: the modification of drug release from
3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene
glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed
release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying
drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed,
characterized, and employed as a fill material for the capsules. Through the preparation and
characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the
study thoroughly investigated its thermal and mechanical properties. Notably, the in
vitro drug release analysis unveiled the intricate interplay between ketoprofen release,
polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the
SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory
activity. These findings collectively underscore the potential of 3D printing in shaping
tailored drug delivery systems, thereby contributing significantly to the advancement of
personalized medicine.

عنوان المؤتمر

Nanoinnovation Conference and Exhibition, Rome , September9-13

دولة المؤتمر

إيطاليا

تاريخ المؤتمر

9 سبتمبر، 2024 - 13 سبتمبر، 2024

راعي المؤتمر

Sapienza Universrity of Rome

معلومات إضافية

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