Extramedullary plasmacytoma (EMP) is an uncommon tumor marked by the monoclonal
growth of plasma cells without the characteristics of multiple myeloma. EMP represents 3%
of all plasma cell tumors. An 89-year-old male patient with hypertension was admitted to
our tertiary care hospital with uncontrolled unilateral epistaxis. After a year and a half of
recurring epistaxis, the patient’s bleeding became more frequent and could no longer be
controlled with nasal packing. Angiofibroma was suspected as the initial differential diag-
nosis, and angiofibroma embolization was performed. The patient experienced difficulty
swallowing and slurred speech and was diagnosed with an ischemic stroke. However, an-
tiplatelet and tranexamic acid medications were contraindicated due to bleeding risks. The
patient underwent functional endoscopic sinus surgery, and unexpectedly, histology results
revealed a plasmacytoma. After surgery,the patient remained stable and was discharged for
further management.
