Gonadoblastoma is a rare ovarian tumor made up of germ cells and gonadal stroma cells, resembling those of dysgerminoma and Sertoli tumors respectively. It usually occurs in individuals with disorders of sex development, particularly in cases of gonadal dysgenesis. However, rare cases where gonadoblastoma developed in phenotypically normal females with normal karyotypes have been reported. Approximately 40% of patients diagnosed with gonadoblastoma present with bilateral involvement 1 . This tumor is considered a premalignant lesion that can potentially transform into a malignant germ cell tumor2 . Wilms tumor (WT), also known as nephroblastoma, is the most common primary renal tumor in children characterized by an embryonal kidney mass affecting approximately 650 children In the United States each year. WT presents a significant clinical challenge due to its potential for aggressive behavior and metastasis 2 . Primary treatment typically involves a combination of surgical intervention, chemotherapy, and radiation therapy, tailored according to the disease stage at diagnosis 2,3 . Despite advances in therapy, WT survivors are at risk of developing secondary malignant neoplasms (SMNs) 4 . This report discusses an 8-year-old girl who developed a bilateral gonadoblastoma four years after being diagnosed with WT. The bilateral gonadoblastoma in this patient, identified through imaging and surgery, highlights the importance of extended Wilms tumor follow-up. This case underscores the need for vigilance in monitoring WT survivors for late-onset complications.

العنوان

authorea

الناشر

wiely

بلد الناشر

الولايات المتحدة الأمريكية

نوع المنشور

مطبوع فقط

المجلد

--

السنة

2025

الصفحات

5