Cypress oilwas analyzed using GC-MS,revealingα-pinene (50.72%) and 3-β-carene (27.57%) asthe major constituents.An optimized nanoemulsion (dropletsize 105.28±2.12 nm, PDI 0.112±0.016) wasincorporated into a carbopol hydrogelto form a stable nanoemulgelwith a zeta potential of –33 mV. The nanoemulgel exhibited enhanced antioxidant activity,with an IC50 of 6.6±0.13 μg ml−1 , compared to 14.7±0.3 μg ml−1 forthe oil alone.It demonstrated potent antimicrobial activity against multiple bacterialstrains,with inhibition zones of 11–36 mm, and antifungal activity againstCandida albicans (16–24 mm). Strong anticancer effectswere observed againstHep-G2 (IC 50 39.81 μg ml−1 ),MCF-7 (IC 50 58.88 μg ml−1 ), andHeLa (IC 50 61.65 μg ml−1 ) cells, alongwith anti-fibrotic activity on LX-2 cells(IC 50 63.09 μg ml−1 ). SelectiveCOX-2 inhibitionwas also confirmed (IC50 13.96 μg ml−1 ).These findings highlightthat cypress oil-loaded nanoemulgel effectively enhancesthe biological activities of cypress oil,suggesting its potential as a therapeutic platform for managing infections, inflammation, and cancer

العنوان

Nano Express

الناشر

IOP Publishing

بلد الناشر

المملكة المتحدة

Indexing

Thomson Reuters

معامل التأثير

2,5

نوع المنشور

Both (Printed and Online)

المجلد

6

السنة

2025

الصفحات

045012