Teucrium polium L, known as felty germander or Palestinian Ja’adeh, primarily flourishes in
Mediterranean countries such as Palestine, Jordan, and Turkey. There has been a significant increase
in the investigation and analysis of essential oils derived from medicinal plants due to their potential
biological and therapeutic applications. This study will investigate the chemical composition of
essential oil derived from the dried leaves of T. polium L. and evaluate its in vitro antioxidant,
anticancer, α-amylase, and lipase inhibitory properties. The essential oil extracted from the dried
leaves of T. polium L. via hydrodistillation was analyzed using gas chromatography-mass spectrometry
(GC-MS) to determine their chemical composition. Sixteen compounds were identified in the essential
oil of T. polium L., with E-nerolidol (27.11%), geranyl acetone (23.26%), germacrene D (19.08%),
β-caryophyllene (17.78%), α-caryophyllene (3.35%), and bicyclogermacrene (3.08%) constitute the
principal components. This essential oil, abundant in oxygenated sesquiterpenes, demonstrated
notable antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) at a concentration of
20.08 ± 1.00 µg/mL. Furthermore, it exhibited significant anticancer effectiveness against the MCF-
7 and B16F10 cell lines, with IC50 values recorded at 30.56 µg/mL and 32.75 µg/mL, respectively.
Nevertheless, it demonstrated restricted lipase activity and insufficient α-amylase activity. The findings
suggest that T. polium L. essential oil is a potential source of natural antioxidants and has anticancer
properties, making it a viable candidate for pharmaceutical and cosmetic use
 

العنوان

Scientific Reports

الناشر

Springer Nature

بلد الناشر

المملكة المتحدة

Indexing

Scopus

معامل التأثير

3,9

نوع المنشور

مطبوع فقط

المجلد

15

السنة

2025

الصفحات

(2025) 15:34371