Multiple Sclerosis (MS) is an autoimmune disease characterized by recurrent episodes
of central nervous system (CNS) demyelination leading to variable clinical symptoms. The
exact etiology and pathogenesis of the disease still remains unknown; however, it is believed
to occur as a result of genetic, environmental and immunological factors. Change in the size
of brain structure is an important issue in patient with multiple sclerosis. Hippocampal
atrophy is the main interested problem in the hippocampus. The aim of the study to find if
there’s a relationship between multiple sclerosis and associated changes in the brain structure
(hippocampus and temporal lobe) which can use later to find if these changes affect patient
memory and learning ability. Magnetic resonance imaging (MRI) was used to obtain brain
images for a total of 5 patient (3 females and 2 males) diagnosed with definite MS according
to An –Najah National University Hospital with age between (18 - 40). A total of 5 healthy
volunteers with no previous history of neurological dysfunction were the control subject (3
males and 2 females) with a range of age between (18-40). A T 1 coronal weighted images
were acquired in a1.5 Tesla Philips scanner. It was found that there’s a change in the size of
the hippocampus in patient with multiple sclerosis compared to the normal patient with the
right side of the hippocampus and have higher percentage of volume loss compared to the left
side. Based on the above result, multiple sclerosis patient suffers from volume loss in
hippocampus but further investigation should be done in more patients and to consider other
factors may have an effect on the hippocampus and temporal lobe volume.

Key words: Multiple Sclerosis (MS), Hippocampal atrophy, Magnetic resonance imaging
(MRI)

عنوان المؤتمر

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دولة المؤتمر

فلسطين

تاريخ المؤتمر

7 أكتوبر، 2017 - 6 أكتوبر، 2017

راعي المؤتمر

PFMR