BACKGROUND AND THE PURPOSE OF THE STUDY: Partition coefficients (log D and log P) and molecular surface area (PSA) are potential predictors of the intestinal permeability of drugs. The aim of this investigation was to evaluate and compare these intestinal permeability indicators.
METHODS:Aqueous solubility data were obtained from literature or calculated using ACD/Labs and ALOGPS. Permeability data were predicted based on log P, log D at pH 6.0 (log D(6.0)), and PSA.
RESULTS:Metoprolol's log P, log D(6.0,) and a PSA of <65 Å correctly predicted 55.9%, 50.8% and 54.2% of permeability classes, respectively. Labetalol's log P, log D(6.0) and PSA correctly predicted 54.2%, 64.4% and 61% of permeability classes, respectively. Log D(6.0) correlated well (81%) with Caco-2 permeability (P(app)). Of the list of national essential medicines, 135 orally administered drugs were classified into biopharmaceutical classification system (BCS). Of these, 57 (42.2%), 28 (20.7%), 44 (32.6%), and 6 (4.4%) were class I, II, III and IV respectively.
CONCLUSION:Log D(6.0) showed better prediction capability than log P. Metoprolol as permeability internal standard was more conservative than labetalol.

العنوان

DARU Journal of Pharmaceutical Sciences

الناشر

BioMed Central

بلد الناشر

المملكة المتحدة

Indexing

Thomson Reuters

معامل التأثير

1,654

نوع المنشور

Both (Printed and Online)

المجلد

19

السنة

2011

الصفحات

83-99