Isoconversional and DFT Investigation of the Thermal Decomposition of Levofloxacin
نوع المنشور
بحث أصيل
المؤلفون
النص الكامل
تحميل

Levofloxacin is a widely used fluoroquinolone antibiotic. In this study, the drug was examined using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The study sought to understand the mechanism of the drug's thermal decompaction, as well as its thermal stability and behavior at elevated temperatures for environmental applications. The TGA was done using various heating rates under N2 gas flow. The isoconversional methods of Kissinger-Akahira-Sunose (KAS) and Friedman were used to determine the  decomposition's effective activation energy (Eα) based on extent of conversion (α). The Eα values of levofloxacin's decomposition ranged from 50-120 and 20-70 kJ/mol for KAS and Friedman, respectively.

المجلة
العنوان
Moroccan Journal of Chemistry
الناشر
Moroccan Center of Development and Science
بلد الناشر
المغرب
Indexing
Scopus
معامل التأثير
2,4
نوع المنشور
Both (Printed and Online)
المجلد
13
السنة
2024
الصفحات
10