Abstract
Background
High-sensitive cardiac troponin T (h-cTnT), which serves as a marker for myocardial damage,
has also been linked to adverse outcomes in asymptomatic hemodialysis patients. This
study aims to explore the correlation between interleukin-6 (IL-6) and h-cTnT in asymptomatic
hemodialysis patients to unravel the relationship between inflammation and cardiovascular
risk.
Methods
A cross-sectional study involving 81 patients was conducted from November 2022 to March
2023 at An-Najah National University Hospital in Palestine. We gathered clinical data,
including comorbidities, and obtained blood samples for measuring IL-6 and h-cTnT levels.
We performed statistical analyses, including correlation tests and linear regression, to
assess the associations between these variables.
Results
The study revealed a notable increase in both h-cTnT and IL-6 levels, and a significant correlation
between the two (rho = 0.463, P<0.001) in asymptomatic hemodialysis patients.
Likewise, h-cTnT levels displayed positive correlations with age (rho = 0.519, P<0.001) and
negative correlations with albumin (rho = -0.297, p = 0.007) and transferrin saturation (rho =
-0.227, P = 0.042). IL-6 levels exhibited correlations with age (rho = 0.422, P<0.001), albumin
(rho = -0.389, P<0.001), iron (rho = -0.382, P<0.001), and transferrin saturation (rho =
-0.362, P = 0.001). Notably, higher h-cTnT levels were associated with diabetes, hypertension,
a history of coronary artery disease, cerebrovascular accidents, older age, and male
gender.