Abstract: To develop a mathematical model describing the behavior of chromophore complexes, the main
factors influencing the stability of poloxamine and poloxamer complexes were determined. Gel permeation
chromatography, ultraviolet absorbance measurements and FT-IR were used for the analysis. It was found
that the studied complexes in chlorinated organic solvents are unstable in the presence of oxygen, air, or water.
The developed mathematical model allows for more effective planning and execution of experiments due
to the possibility of predicting UV absorption based on the distribution of complexes in chlorinated solvents.
Keywords: poloxamines, poloxamers, block copolymers, ammonium ferrothiocyanate, colorimetric
analysis, mathematical modeling.