A Quantitative Prospective Study for Whole Body- Diffusion MRI and PET-CT in Detection of Primary and Metastatic Malignant Lesions
نوع المنشور
بحث أصيل
المؤلفون

The idea of an integrated nuclear medicine unit consisting of a PET-CT scanner with a practical source of radioisotopes such as a cyclotron to operate efficiently in Palestinian health system is almost impossible due to several reasons, mainly political and financial issues.

The goal of this study is to find a safe, valid, and widely available modality as an alternative to help oncologists and patients; we proposed a whole-body diffusion MRI protocol (WB-DWI MRI)

A 33 oncological patients, 60% male (n = 20) and 40% female (n = 13), age 18-74 years with a mean age of 48 years old participated in our study for a PET-CT and WB-DWI MRI scan.

Participants already diagnosed to have primary tumors including non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma, endometrial cancer, prostate cancer, pancreatic cancer, gastric cancer, thyroid cancer, idiopathic pathological fractures and skin lesions suspected to be melanoma.

Our results shows that PET-CT demonstrated 181 hypermetabolic lesion distributed in the four zones ( head-neck, chest, abdomen-pelvis and musculoskeletal), was detected by WB-DWI MRI which shows most of the same lesions restricted in diffusion with extra small sub centimeter lesions totally 251 lesions in count with a comparison between standard uptake volume (SUV) and apparent diffusion coefficient ADC) which shows most high SUV( SUV>2.5) have ADC < 1.1 x10-3 mm2/S. Statistical quantitative analysis shows a significant positive correlation between number of detected lesions in the same zone for each patient at p value < 0.05 (p=0.00004) and R-value = 0.5335, a comparative correlation between ADC and SUV shows a significant negative correlation between SUV and ADC at p value < 0.05 and R-value= -0.3073. WB-DWI MRI can replace PET-CT scan in lymphoma cases and tumors follow up to monitor the response for treatment after chemotherapy or radiotherapy either post-surgical resection.

المجلة
العنوان
Proceedings of the 2022 5th International Conference on Digital Medicine and Image Processing
الناشر
Association for Computing Machinery New York, NY, United States
بلد الناشر
الولايات المتحدة الأمريكية
نوع المنشور
Both (Printed and Online)
المجلد
--
السنة
2023
الصفحات
63–71