N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff  base was isolated  and characterized as Zisomer. Ethanoic reflux condensation of equivalent  amount of nicotinohydrazideand with 5bromothiophene-2-carbaldehyde produced  the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.

العنوان

Moroccan Journal of Chemistry 4(1),259-269

الناشر

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بلد الناشر

فلسطين

نوع المنشور

Both (Printed and Online)

المجلد

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السنة

2016

الصفحات

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