Objective: In this study, the effects of three different ozonated oils (Sesame, Nigella sativa, and Hypericum perforatum) on wound closure rate, healing process, and possible complications were examined macroscopically and microscopically.
Materials and Methods: Twenty-one adult Wistar albino female rats were used in the study. Subjects were divided into three groups, early wound healing, (7 days), medium wound healing, (14 days), and late wound healing (21 days). Four full-thickness skin wounds of equal size (10 mm in diameter) were formed on the back regions of all rats. This region was chosen for preventing self-inflicted injuries and reducing external irritation. The wound was left open during the healing process. While the first wound (control) received no treatment in the second wound, ozonated Sesame oil, in the third wound ozonated Nigella sativa oil, and in the fourth wound ozonated Hypericum perforatum oil were used. No group obtained parenteral drug administration. The first, second, and third main groups were euthanized on days 7, 14, and 21, respectively. The wound healing was assessed macroscopically daily. Wound sizes of individual rats were measured with a caliper and digitally photographed every day from the day of injury. After euthanasia, all wound sites of the subjects were evaluated histopathologically.
Results: There were no significant differences in wound healing between treatments on the first day 7. On the 14, it was found that the healing was better in the group that applied Nigella sativa and Sesame oils (p≤0.05). On day 21 wound healing was completed in all subjects with a resultant of better outcome in Nigella sativa oil treatment compared with others (p≤0.01).
Conclusion: In this study, the best wound healing outcome was achieved with Nigella sativa oil and Sesame oil where three different minced oils were used.

العنوان

Turkish Journal of Veterinary Research

الناشر

Fırat Üniversitesi Araştırma Projeleri Birimi

بلد الناشر

تركيا

نوع المنشور

إلكتروني فقط

المجلد

5

السنة

2021

الصفحات

9