Abstract: The gradual replacement of Ca2+ with Cu2+ ions in brushite (CaHPO4
2H2O) has been
extensively studied and discussed. The approach adopted in this work has not been systematically
explored in previous studies. This novel approach may prove beneficial for the production of
Ca1????xCuxHPO4
nH2O materials with desired properties suitable for medical applications. Solutions
of sodium dihydrogen orthophosphate dihydrate, NaH2PO4
2H2O, calcium nitrate tetrahydrate,
Ca(NO3)2
4H2O, copper nitrate trihydrate, Cu(NO3)2
3H2O, ammonium hydroxide solution, and
diluted HCl were used for the preparation of these materials. At low Cu/Ca molar ratios (up to
0.25) in the starting solution, biphasic phosphate minerals were formed: brushite and sampleite.
When the Cu/Ca molar ratio increases gradually from 0.67 to 1.5, sampleite-like mineral precipitates.
Powdered XRD (X-ray diffraction), thermogravimetric (TG) analysis, and SEM (scanning electron
microscopy) techniques were employed for the study of the microstructure of the produced materials
for different degrees of Ca replacement with Mg. It is found that the Cu/Ca ratio in the starting
solution can be adjusted to obtain materials with tailored composition. Thus, a new method of
sampleite-like synthesis as a rare mineral is introduced in this study. Both phosphate minerals
brushite and sampleite-like minerals are attractive as precursors of bioceramics and biocements. The
search for such products that may decrease the possibility of post prosthetic or implant infection can
be crucial in preventing devastating post-surgical complications.
Keywords: brushite; sampleite; biomaterials; XRD; crystal growth
1. Introduction
Calcium phosphate

العنوان

minerals

الناشر

MDPI

بلد الناشر

سويسرا

Indexing

Scopus

معامل التأثير

None

نوع المنشور

إلكتروني فقط

المجلد

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السنة

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الصفحات

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