Pharmaceutical nanotechnology is an emerging technology that proved its effectiveness in decreasing the side effects and improving the therapeutic outcomes of chemotherapeutic drugs. Combretastatin A4 (CA4) is a natural potent tubulin polymerization inhibitor. However, it suffers from low water solubility with various side effects. The aim of this study was to formulate and characterize poly (lactide-co-glycolide)(PLGA) nanoparticles loaded with CA4, to assess its release kinetics and to evaluate the in vitro cytotoxic activity of the obtained nanoparticles. CA4 was synthesized according to a previous protocol. Nano-precipitation and emulsion evaporation methods were used to produce the desired drug-loaded PLGA nanoparticles. The obtained nanoparticles were characterized for shape, particle size, zeta-potential, encapsulation efficiency (EE), drug loading (DL) and release kinetics. Cytotoxicity and IC 50 of the …

العنوان

Materials Research Express

الناشر

IOP Publishing

بلد الناشر

المملكة المتحدة

Indexing

Thomson Reuters

معامل التأثير

1,6

نوع المنشور

إلكتروني فقط

المجلد

6

السنة

2020

الصفحات

1250d7