Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used therapeutics; they are competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the conversion of arachidonic acid to inflammatory prostaglandins.

Objective:

In this study, new benzodioxol derivatives with different core cycles and functional groups (i.e., aryl acetate, aryl acetic acid and diazepine) were designed, synthesized, identified and evaluated for their analgesic and anti-inflammatory activity, as a preliminary screening study to identify the most potent and more selective groups.

Methods:

The synthesized compounds were identified using FTIR, HRMS, 1H-NMR and 13C-NMR, and evaluated for their inhibitory activity against ovine COX-1 and COX-2 using an in vitro cyclooxygenase (COX) inhibition assay kit.

Results and Discussion:

Six compounds were synthesized as a preliminary screening …

العنوان

Letters in Drug Design & Discovery

الناشر

Bentham Science Publisher

بلد الناشر

الإمارات العربية المتحدة

Indexing

Thomson Reuters

معامل التأثير

1,1

نوع المنشور

إلكتروني فقط

المجلد

17

السنة

2020

الصفحات

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