Extractional - Spectrophotometric Determination
- Publication Type
- Original research
- Authors
- ALl Z. ABU ZUHRI
- WOLFGANG VOELTER
- Suleiman Ibrahim Al-khalil
- IMAD SALAHAT
Methods for spectrophotometric determination of fenbendazole and
ornidazde are described. The methods are based on the formation and
extraction of the ion-pair complex formed between bromothymol blue and
either fenbendazole (FBZ) or ornidazole (ORN’). The extracted coloured
complexes absorb at 416 and 446 nm, respectively. The effect of
different factors, e.g. pH, organic solvent, reagent concentration,
extraction time, shaking time and common interfering species have been
investigated.Fenbendazole and ornidazole can be determined over the
range 1.2 to 24.0 ppm and 5.5 to 77.0 ppm, respectively. The precision
of the methods was tested for the determination of pure samples of FBZ
and ORN and the mean RSD was found to be 3.0 and 2.3% for FBZ and ORN,
respectively.
Journal
- Title
- Scientia Pharmaceutica (Sci. Pharm.) 68, 109—122 (2000)
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2000
- Pages
- --